Abstract
Rationale: Patients affected by Head and Neck Cancer (HNC) may experience both weight loss and fat free mass loss, since the early phases of the disease and during(chemo)radiotherapy. Oral feeding may be difficult due to nausea, anorexia, dysfagia, xerostomia, mucositis and other swallowing disorders, while the disease-related systemic inflammation may disrupt normal energy balance and substrate metabolism. Weight loss up to 10% of pre-treatment body weight may occur while undergoing chemo(radiotherapy), and this often leads to a state of malnutrition.Malnutrition and sarcopenia are both associated to poorer outcomes and overall survival in HNC.The aim of this study was to assess changes in weight and body composition in a group of patients referred to the Clinical Nutrition Unit of Bellaria Hospital (Bologna) for intensive nutritional care while undergoing (chemo)radiotherapy for HNC.
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