Body composition and ventricular function in hemodialysis patients.

Abstract

There is no evidence about the potential role of body composition on cardiovascular mortality in dialysis patients. The aim of this study was to assess the relationship between body composition and changes in ventricular function. We conducted an observational study over a population of 78 patients on chronic hemodialysis. A transthoracic echocardiogram and a bioimpedance were performed at the beginning and at the end of the study. The mean follow-up time was 30.6months. Patients who had a higher fat tissue index (FTI>9.20kg/m2 ) experienced a worsening in right and left ventricular function. They developed a greater fall in tricuspid annular plane systolic excursion (TAPSE) (-1±4.3mm) and left ventricular ejection fraction (LVEF)(-4.2±6.8%), compared to those with lower FTI (p=0.032 and p=0.045, respectively). No associations were found between any other echocardiography or body composition parameters and overall mortality. Patients with right ventricular dysfunction (determined as TAPSE) experienced a tendency to higher mortality rate along the study (HR for mortality of 13.5 (95% CI, 1.1-166.7; p=0.041)]. A higher fat tissue index could be associated with a deleterious effect over right and left ventricular function in dialysis patients.