Abstract
ObjectiveWomen with Hashimoto thyroiditis (HT) are characterized by increased incidence of infertility and disturbances in body composition. Serum anti-Müllerian hormone (AMH), which reflects functional ovarian reserve, is decreased in women with HT and it be related to body mass. The aim of the present study was to investigate the relation between serum levels of AMH and body composition in HT compared to control group.Patients and MethodsWe examined 85 euthyroid women: 39 subjects with HT and 46 control women. Body composition was analysed by dual-energy X-ray absorptiometry and with bioimpedance method. Serum concentrations of AMH, leptin, TSH, thyroid hormones were assessed.ResultsWe observed lower serum concentration of AMH in women with HT in comparison to the control group (p=0.01), but without differences in serum concentration of leptin between studied groups (p=0.28). Women with HT were characterized by higher %body fat (p=0.01) estimated with bioimpedance method without differences in BMI, android and gynoid fat mass and visceral adipose tissue (VAT) mass estimated with DXA method when compared to the control group (all p>0.05). We found a negative relationship between serum concentration of AMH and %body fat (r=-0.38,p=0.03) in women with HT. Additionally, in HT group, the relationship between serum levels of AMH and leptin was not statistically significant (r=0.01,p=0.96). We observed a relationship between serum concentration of leptin and BMI, %body fat mass, android, gynoid and VAT mass in HT and in the control group (all p<0.01).ConclusionsWomen with HT are characterized by lower levels of AMH and it is associated with higher fat mass, independently of serum levels of leptin.
Highlights
Ovarian reserve is defined as the number of oocytes remaining in the ovary, or oocyte quantity which are the population of nongrowing, i.e., primordial, follicles
Women with Hashimoto thyroiditis (HT) were characterized by higher %body fat (p=0.01) estimated with bioimpedance method without differences in BMI, android and gynoid fat mass and visceral adipose tissue (VAT) mass estimated with Dual-energy X-ray absorptiometry (DXA) method when compared to the control group
Women with HT are characterized by lower levels of anti-Müllerian hormone (AMH) and it is associated with higher fat mass, independently of serum levels of leptin
Summary
Ovarian reserve is defined as the number of oocytes remaining in the ovary, or oocyte quantity (oocyte number) which are the population of nongrowing, i.e., primordial, follicles. The prevalence of diminished ovarian reserve in women is about 24% [3]. It has been identified that smoking, previous ovarian surgery, pelvic irradiation, previous chemotherapy, as well as genetic causes are connected with diminished ovarian reserve [4]. The assessment of functional ovarian reserve includes the levels of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), inhibin B, and estradiol, and sonographically measured features of the ovaries, e.g. antral follicle count (AFC). These markers can be useful as predictors of oocyte yield following controlled ovarian stimulation and oocyte retrieval [1, 6]
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