Abstract
Background and Objectives: The aim was to compare body composition and levels of biochemical blood parameters and identify relationships between biochemical parameters and body composition of women with type 2 diabetes and healthy ones, both in perimenopausal period (172 women aged between 45 and 65 come from the West Pomeranian Voivodeship, Poland). Materials and Methods: The study consisted of an interview, body composition analysis with Jawon Medical IOI-353 (Yuseong, South Korea) analyser and venous blood biochemical analysis (lipid profile, levels of glucose, insulin, CRP, glycated haemoglobin). Results: The vast majority of body composition measurements varied between study and control groups in a statistically significant way (p < 0.05) except protein and soft lean mass of the torso. Statistically significant differences between the two groups have been observed in case of all biochemical parameters (p < 0.001). Conclusions: Body composition of women suffering from type 2 diabetes significantly varied from body composition of healthy women. Results of the first group were characterised by higher values, especially in case of general parameters, abdominal area, content of adipose tissue and soft tissues. Relationship between body composition and biochemical results may be observed, especially in level of triglycerides, CRP and insulin. Higher concentrations of these parameters were associated with increased values of majority of body composition measurements regardless of type 2 diabetes incidence.
Highlights
The perimenopausal period is the time of numerous changes in a woman’s life—changes in biological, mental, social, and cultural spheres
Hormonal disorders cause an increase in body mass, influence distribution of adipose tissue, reduce energy expenditure and decrease insulin secretion and sensitivity of cells to this hormone, all of which predispose to the development of type 2 diabetes [1,2,3,4]
Our study showed that higher C-reactive protein (CRP) levels are associated with increased values of most body composition parameters both in women with type 2 diabetes and in healthy controls
Summary
The perimenopausal period is the time of numerous changes in a woman’s life—changes in biological, mental, social, and cultural spheres. The perimenopausal period is the time of numerous changes in a woman’s life—. Symptoms resulting from hormonal changes, caused by decreasing hormonal function of ovaries and a plummeting level of endogenous oestrogen, result in adverse changes in glucose and insulin metabolism, adipose tissue distribution, coagulation cascade disorders, and endothelium dysfunction. The severity and type of symptoms vary from individual to individual due to genetic predispositions and environmental factors. Hormonal disorders cause an increase in body mass, influence distribution of adipose tissue, reduce energy expenditure and decrease insulin secretion and sensitivity of cells to this hormone, all of which predispose to the development of type 2 diabetes [1,2,3,4]. Decreased sensitivity of cells to insulin is rather associated with adipose tissue distribution than its total mass. Perimenopausal women were characterized by hormonal changes and by various phenotypic and biochemical changes that could predispose them to the
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