Body Composition Analysis Allows the Prediction of Urinary Creatinine Excretion and of Renal Function in Chronic Kidney Disease Patients.

Carlo Donadio

doi:10.3390/nu9060553

Abstract

The aim of this study was to predict urinary creatinine excretion (UCr), creatinine clearance (CCr) and the glomerular filtration rate (GFR) from body composition analysis. Body cell mass (BCM) is the compartment which contains muscle mass, which is where creatinine is generated. BCM was measured with body impedance analysis in 165 chronic kidney disease (CKD) adult patients (72 women) with serum creatinine (SCr) 0.6–14.4 mg/dL. The GFR was measured (99mTc-DTPA) and was predicted using the Modification of Diet in Renal Disease (MDRD) formula. The other examined parameters were SCr, 24-h UCr and measured 24-h CCr (mCCr). A strict linear correlation was found between 24-h UCr and BCM (r = 0.772). Multiple linear regression (MR) indicated that UCr was positively correlated with BCM, body weight and male gender, and negatively correlated with age and SCr. UCr predicted using the MR equation (MR-UCr) was quite similar to 24-h UCr. CCr predicted from MR-UCr and SCr (MR-BCM-CCr) was very similar to mCCr with a high correlation (r = 0.950), concordance and a low prediction error (8.9 mL/min/1.73 m2). From the relationship between the GFR and the BCM/SCr ratio, we predicted the GFR (BCM GFR). The BCM GFR was very similar to the GFR with a high correlation (r = 0.906), concordance and a low prediction error (12.4 mL/min/1.73 m2). In CKD patients, UCr, CCr and the GFR can be predicted from body composition analysis.

Highlights

An accurate evaluation of renal function is important in chronic kidney disease (CKD) patients to classify the stage of CKD, to evaluate the progression of kidney impairment and to prevent toxic effects due to inappropriate dosage of drugs
Mg/24 h urinary creatinine, mg/24 h found between women and men in body weight (BW), body surface area (BSA), fat mass, extra-cellular water, Body cell mass (BCM), serum creatinine (SCr), 24-h urinary creatinine excretion (UCr), and
24-h 2017, UCr/BW, while no differences were found in body mass index (BMI) and in the ratio of 24-h

Summary

Introduction

An accurate evaluation of renal function is important in chronic kidney disease (CKD) patients to classify the stage of CKD, to evaluate the progression of kidney impairment and to prevent toxic effects due to inappropriate dosage of drugs. SCr levels are influenced by the amount of muscle mass

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Results

Conclusion