Abstract
Feeding male Wistar rats 50 or 100 ppm HCB in the diet for 62 days evoked induction of liver esterase activity toward thiophenyl, p-nitrophenyl, and indophenyl acetates. The induction rate, as well as the HCB residues, in liver, brain, kidney, and heart were dose-dependent. An increase in esterase activity toward thiophenyl acetate was also observed in the kidney at the 100-ppm HCB level. Serum esterase activity toward malaoxon was elevated at 50 and 100 ppm HCB and that toward paraoxon was increased at 100 ppm. Liver esterase hydrolysis of malaoxon was induced only at 100 ppm HCB. Under the condition used, the rats fed 10 ppm HCB were observed to be similar to the controls; the concentrations of HCB residues found in the liver, brain, kidney, and heart were dose dependent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.