Abstract
Abstract The preparation of substituted amide from the reaction between a simple aliphatic or aromatic ester and an aminomagnesium halide (1:2 ratio) obtained by treatment of a primary or secondary amine with a Grignard reagent at room temperature is known as Bodroux amide synthesis. The direct aminolysis of carboxylic esters with primary amines need high temperatures and the use of an autoclave. Other metal amides have also been developed. This reaction has been modified as the reaction between esters and lithium aluminum amide. More recent modifications for this reaction include the reaction between a carboxylate, amine, and Grignard reagent in a 1:1:1.5 molar ratio.
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