Abstract
Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds 1–7 were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds 2 and 5 exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively.
Highlights
Elsholtzia bodinieri Vaniot (Chinese name “Dongzisu”), belonging to the taxonomically diverse group of the family Labiatae, is a medicinal plant that grows in Yunnan and Guizhou Provinces in China
Previous studies on E. bodinieri led to the isolation of triterpenoid saponins [2,3,4,5,6], flavonoid glycosides [7,8], sesquiterpene glycosides [9], clerodane diterpenoid glycosides [10], and phenolic constituents [11] from the aerial parts of this plant
The results demonstrated that compounds 2 and 5 exhibited potent inhibition of influenza virus activities, with inhibition rates of 35.33% and
Summary
Elsholtzia bodinieri Vaniot (Chinese name “Dongzisu”), belonging to the taxonomically diverse group of the family Labiatae, is a medicinal plant that grows in Yunnan and Guizhou Provinces in China. It is commonly known as “yashuacao” and is used as a traditional Chinese medicine for the treatment of cough, headache, pharyngitis, fever and hepatitis [1]. In our search for secondary metabolites with structural diversity and potential anti-influenza virus activity, seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.), were obtained from E. bodinieri. We report the isolation, structural elucidation and anti-influenza virus activities of the isolated compounds
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