BNP: phenotypic features of plasma concentration of biomarkers through the prism of sexual dimorphism

Abstract

Annotation. The aim of the study is to clarify the borderline levels of plasma concentration of BNP (B-type natriuretic peptide), with the carriage of polymorphic variants of the BNP gene in persons without cardiovascular pathology in the Podolsk region of Ukraine. Using general clinical, instrumental and laboratory methods, 67 postmenopausal women and 79 men 40–60 years old without signs of cardiovascular pathology were examined. BNP gene genotyping was performed by polymerase chain reaction. Plasma concentrations of natriuretic peptide were determined by plate solid-phase enzyme immunoassay. Mathematical processing was carried out on a personal computer using the standard statistical package Statistica 10.0. It has been established that both female and male residents of the Podolsk region of Ukraine have the same frequency of distribution of polymorphic variants of the BNP gene. Plasma concentrations of natriuretic peptide are determined by gender characteristics and are significantly higher in women: 38.32±0.65 pg/ml versus 21.74±0.50 pg/ml. in men (p<0.05). Moreover, in women, BMI is inversely correlated with the level of BNP in blood plasma.