Abstract
BMPs: Conserved Morphogens in Neural Patterning
Highlights
Fusion of two plasma membranes is central to exocytosis, the process by which a cell secretes neurotransmitters, digestive enzymes, and other products
When the others bind to their respective SNAREs, they leave the SNAREs in an open conformation, available for interacting with others and forming the complexes that drive membrane fusion
Synaptobrevin is a known partner for syntaxin, and it has been shown that the addition of synaptobrevin drives syntaxin in conjunction with SNAP-25 into SNARE complexes
Summary
Fusion of two plasma membranes is central to exocytosis, the process by which a cell secretes neurotransmitters, digestive enzymes, and other products. By deleting SNAP-25, the authors verified its essential role in displacing Munc181 from syntaxin, suggesting there is an intermediate complex formed by Munc, syntaxin, synaptobrevin, and SNAP-25 These results shed light on the actual function of Munc, but allow the development of a more coherent picture of SM proteins, in which Munc is no longer the oddball. HIV-1 exploits retrograde transport of tRNAs in human cells to promote nuclear import of its reverse transcription complex. Using a high-speed centrifuge, they separated cytoplasm from cultured cells into fractions and tested each fraction for its ability to promote nuclear import of the RTCs in the gutted cells As expected, when they added in the fraction containing several known nuclear transport factors, the RTCs could enter the nucleus.
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