Abstract
Purpose: The fibrocartilage chondrocyte phenotype has been recognized as a pathological chondrocyte in osteoarthritic (OA) articular cartilage. Although relatively rare and mainly found in late-stage OA, the fibrocartilage chondrocyte expresses a high ratio of genes related to unfavorable OA outcomes, emphasizing its importance in OA disease development. Development of the fibrocartilage chondrocyte phenotype resembles fibrotic processes also observed in other tissues. BMP7 is being explored as a potential disease-modifying molecule reversing the hypertrophic chondrocyte phenotype in OA.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
