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Abstract
Bone morphogenetic proteins (BMPs) are crucial growth factors from embryonic development up to adult organ/tissue homeostasis since they regulate versatile processes such as stem cell maintenance, differentiation and migration. Aberrant signalling leads to pathologies including cancer or musculoskeletal and vascular diseases. Here, we provide an overview of the BMP signalling cascade and its complex regulation and show how we investigate this tightly controlled protein network in physiological and pathological model systems.
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