Abstract
A more complex, but clearer, picture is emerging for the role of certain bone morphogenetic proteins (BMPs) and their role in olfactory epithelium (OE) neurogenesis. Evidence presented in a paper by Anne Calof and colleagues demonstrates that in addition to inhibiting neurogenesis, certain BMPs, such as BMP4, may promote OE neurogenesis. Importantly, BMP4 does not affect proliferation of progenitor cells. How are these differential effects achieved? The type of BMP appears to be a factor, as does its concentration; other important determinants are cell type and lineage state. Another control point is provided by endogenous regulators of BMPs such as noggin, which itself is regulated by noggin-binding factors produced by OE stroma. By inhibiting proliferation of progenitor cells but stimulating neurogeneisis, these data may provide a potential explanation for the slowing rate of neurogenesis in the developing CNS. Development (2000) 127, 5403–5413.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
