Abstract
The development of glioma-specific nanoparticles is an area of intense research recently. Fluorescent nanodiamonds (FND) as optical probes to image biological systems have attracted considerable attention. In this paper, the glioma-specific nanoparticles FND-conjugated with BmK CT, a key chlorotoxin-like peptide isolated from the scorpion venom of Buthus martensii Karsch, were developed. The receptor-mediated uptake of FND- BmK CT bioconjugates into rat C6 glioma cells and direct tumor visualization were confirmed by confocal fluorescence assay. Moreover, FND- BmK CT had high inhibition rate during the migration of rat C6 glioma cells by in vitro wound healing assay. These glioma-specific multifunctional nanoparticles FND- BmK CT might be responsible for the development of more effective therapeutic agents in clinical treatment of glioma.
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