Abstract
An ecofriendly, simple, and efficient one-pot protocol has been developed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by the reaction of benzil, aryl aldehydes, aliphatic or aromatic amines, and ammonium acetate, catalyzed by the acidic halogen-free ionic liquid [bmim]HSO4 under solvent-free conditions. The advantages of the proposed protocol include high yields, short reaction time, operational simplicity, and recyclability of the catalyst. Eight previously unknown tetrasubstituted imidazoles were synthesized, among which those bearing a cyclopropyl substituent on N1 can be considered as potential mutant isocitrate dehydrogenase 1 (IDH1) inhibitors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
