Abstract
ObjectivesTo determine if obesity and serum lipid parameters are associated with increased risk and more aggressive prostate cancer in Chinese populationMaterials and MethodsWe conducted a retrospective cohort analysis including 3102 patients. Kruskal-Wallis test for continuous variables and the chi-squared tests for categorical variables were used for univariate comparison of the differences in patient characteristics across BMI categories between different groups. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for the association between prostate cancer and the various patient characteristics. Multivariable Cox proportional hazards regression was performed to assess the risk of prostate cancer recurrenceResults974 consecutive men were diagnosed as prostate cancer and 700 patients subsequently received radical prostatectomy immediately, and 1031 patients were pathologically diagnosed as biopsy negative. The level of low-density-lipoprotein cholesterol (LDL-c) and total cholesterol was significantly higher and the high-density-lipoprotein cholesterol (HDL-c) level is much lower in prostate cancer patients. Patients with low level of HDL-c, who subsequently received radical prostatectomy, had increased risk of high risk disease. In addition, patients with normal weight were less likely to develop a biochemical recurrence. Combined analysis revealed that obese patients had significantly higher rates of PSA recurrence over time than nonobese patients.ConclusionsIn our study, lipid parameters are supposed to be associated with prostate cancer risk and aggressiveness. Obese men are at increased risk of PSA recurrence after radical prostatectomy.
Highlights
Prostate cancer (PCa) is the most prevalent kind of malignancies and the second leading cause of cancer deaths in North American
974 consecutive men were diagnosed as prostate cancer and 700 patients subsequently received radical prostatectomy immediately, and 1031 patients were pathologically diagnosed as biopsy negative
The level of low-density-lipoprotein cholesterol (LDL-c) and total cholesterol was significantly higher and the high-densitylipoprotein cholesterol (HDL-c) level is much lower in prostate cancer patients
Summary
Prostate cancer (PCa) is the most prevalent kind of malignancies and the second leading cause of cancer deaths in North American. In Asian, data shows that the incidence of the PCa is much lower compared with the Western countries [1]. The rates have risen rapidly in the past two decades in most Asian countries www.impactjournals.com/oncotarget [2], which is even faster than Western world, and in China, PCa has become the most common malignant cancer of male urogenital system. Study concerning the incidence of PCa between the indigenous American population and Asian immigrants shows that the differences are reducing [2], reflecting that environmental factors, in particular the influence of diet and the ‘‘Western lifestyle,’’ are supposed to contribute to the pathogenesis of this disease
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