Abstract
Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise. Muscle specimens obtained before and after 24 weeks of exercise in older people with HIV (PWH; n = 18; ART >2 years) and uninfected controls (n = 21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content. Only controls had increased CS, MnSOD, PGC1α, and CIV (P ≤ .01; P < .01 vs PWH) after training. The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation. NCT02404792.
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