Abstract
Irisin is a novel myokine associated with increased metabolism, which may be upregulated in type 1 diabetes (T1D) during exercise-heat stress. We therefore assessed serum irisin production in young adults with and without T1D during incremental exercise in dry-heat (35 °C). The change in irisin during exercise was lower in individuals with compared with without T1D (-1.79 (SEM 25.68) vs. 59.74 (SEM 79.63) pg/mL; p = 0.024), indicating that irisin expression during exercise-heat stress is blunted in T1D. Novelty We show that, when assessed in young adults with and without T1D during exercise-heat stress, serum irisin production is blunted in T1D.
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