Abstract
Various berries demonstrate antioxidant activity, and this effect is expected to prevent chronic diseases. We examined whether a diet containing blueberry powder could prevent the development of bladder dysfunction secondary to bladder outlet obstruction (BOO). Eighteen 8-week-old male Sprague-Dawley rats were randomly divided into three groups: Sham (sham operated + normal diet), N-BOO (BOO operated + normal diet) and B-BOO (BOO operated + blueberry diet). Four weeks after BOO surgery, the N-BOO group developed bladder dysfunction with detrusor overactivity. The B-BOO group showed significantly improved micturition volume and micturition interval. The urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were measured as oxidative stress markers. In the N-BOO group, 8-OHdG increased 1.6-fold and MDA increased 1.3-fold at 4 weeks after surgery, whereas the increase in 8-OHdG was significantly reduced by 1.1-fold, despite a similar increase in MDA, in the B-BOO group. Bladder remodeling was confirmed due to bladder hypertrophy, fibrosis and increased connexin43 expression in the N-BOO group, but these histological changes were reduced in the B-BOO group. The intake of blueberries prevented the development of bladder dysfunction secondary to BOO. This effect seems to be related to antioxidation and the inhibition of bladder remodeling.
Highlights
Blueberries are widely consumed as a health food around the world
We focused on one of the non-neurogenic Overactive bladder (OAB) induced by bladder outlet obstruction (BOO), with benign prostatic enlargement (BPE)
We examined whether the ingestion of diets containing blueberries could replicate the health benefits in rats with BOO
Summary
Blueberries are widely consumed as a health food around the world. The bioactive components of blueberries demonstrate anti-oxidative, anti-inflammatory and anti-cancer effects [1,2,3,4]. The mechanisms underlying OAB with associated BPE are considered to involve mechanical obstruction of the urethra and functional obstruction due to smooth muscle contraction from the bladder neck to the prostatic urethra resulting from an enlarged prostate. These changes lead to extension, increased pressure and bladder ischemia, and cause irritability of the bladder smooth muscle and hyperactivity of the afferent nerve with denervation supersensitivity [19]. We hypothesized that components within blueberries could prevent the development of bladder dysfunction by attenuating chronic oxidative stress. In this study, we investigated whether the intake of a diet containing dried blueberry powder in rats with bladder outlet obstruction could prevent or attenuate the development of bladder dysfunction
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