Abstract
Background Interventional therapy has been widely used in the medical field as its advantages of minimally invasive, safe and quick recovery. Bloodstream infection (BSI) is the most common healthcare-associated infections (HAIs) after interventional therapy, but there are few reports about it. This study intends to analyze the clinical characteristics and relevant factors of BSI after six years of interventional therapy in a large tertiary teaching hospital, in order to provide guidances for the prevention and control of BSI after interventional operations. Methods The case information of patients with BSI after interventional therapy from 2013 to 2018 were collected through the "real-time monitoring system of healthcare-associated infections". All BSI was determined by the infection control full-time staff and clinicians. Questionnaires were designed to review case by case and register the relevant patient information into a database. A total of 18 relevant factors were counted. Statistical software was used for analysis. Results174 cases of BSI occurred in 25401 patients, the incidence was 0.69%, and BSI accounted for 50% of all infected sites. Gram-positive bacteria accounted for 56.05%, coagulase-negative Staphylococcus was the main infectious bacteria. Relevant risk factor analysis showed that hepatocellular carcinoma, had undergone surgery, biliary complications, prophylactic antibiotic, replacement of antibiotics, number of interventional operations, days of prophylactic antibiotic use were the related risk factors associated with BSI (P < 0.05). Multivariate analysis showed that days of prophylactic antibiotic use (OR = 1.586, P < 0.05) and replacement of antibiotics (OR = 13.349, P < 0.05) were the main risk factors associated with the development of BSI. Conclusions BSI is the main infection site after interventional surgery. For patients with the risk factors as hepatocellular carcinoma/biliary complications/had undergone surgery etc., the time of prophylactic antibiotic use can be prolonged properly before interventional surgery, and selection of single antibiotic appropriate for use could significantly aid preventive measures to avoid occurrence of BSI.
Highlights
Interventional therapy, with its advantages of minimally invasive, safe and rapid recovery, has been rapidly developed since its application in medical treatment in the 1970s, especially in the diagnosis and treatment of hepatocellular carcinoma (HCC) and hepatobiliary diseases [1]
Under the condition of no exposure to the lesion, it uses catheters, guide wires and other devices to carry out minimal trauma treatment for some lesions under the guidance of imaging devices (X-ray, ultrasound, CT, MRI) [2]. Many invasive operations such as puncture, intubation, and drug injection need to be performed during interventional operation, and extended length of stay in hospital environment a er operation provides a way for pathogenic bacteria to invade. erefore, Healthcareassociated Infections (HAIs) is the most common complication [3,4,5]
Pathogenic Bacteria. 157 pathogenic bacteria were detected from 119 patients. e majority (88, 56.05%) were Gram-positive bacteria. e most prevalent isolates were Coagulase-negative Staphylococcus (CNS) (48, 30.57%) and Escherichia coli (32, 20.38%)
Summary
Interventional therapy, with its advantages of minimally invasive, safe and rapid recovery, has been rapidly developed since its application in medical treatment in the 1970s, especially in the diagnosis and treatment of hepatocellular carcinoma (HCC) and hepatobiliary diseases [1]. Erefore, it is important to find out the risky factors of BSI in time and give effective treatment as soon as possible for the rehabilitation of patients a er operation To our knowledge, this type of study focused on the analysis of the infection situation of specific treatment methods. Is study analyzed the clinical characteristics and relevant risk factors of BSI a er interventional therapy in a large hospital from 2013 to 2018, aiming at providing guidances for prevention and control of BSI. Is study intends to analyze the clinical characteristics and relevant factors of BSI a er six years of interventional therapy in a large tertiary teaching hospital, in order to provide guidances for the prevention and control of BSI a er interventional operations. Relevant risk factor analysis showed that hepatocellular carcinoma, had undergone surgery, biliary complications, prophylactic antibiotic, replacement of antibiotics, number of interventional operations, days of prophylactic antibiotic use were the related risk factors associated with
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