Abstract
emphasized a primary interest of investiga tors in development of adequate methods for determination of blood volume and for establishment of ranges of values in healthy and in diseased states. By 1960, there was fairly general agreement that available methods gave a reasonable measure of blood volume; Reeve, Allen & Roberts (3), work ing on this assumption, devoted their review to an elegant mathematically oriented discussion, based on a simplified model, of factors controlling plasma volume. They were concerned chiefly with factors affecting steady state distribution of water, prot ein, and soluble fluxes through organism, regulation of total erythrocyte volume, and interactions between red cell and plasma volume. Their concluding paragraph on Integration of Factors Controlling Blood Volume indicated various possibilities for interaction of reflex and humoral factors, a discussion which presaged later more de tailed review by Farrell & Taylor (4). These authors emphasized neuro endocrine aspects of blood volume regulation and the emergence of a unify ing concept that certain elements of blood volume regulation (the control of water and electrolyte balance) may be by systems analogous to those for maintenance of arterial
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