Abstract
Recent advances in the surgical technique and other therapeutic maneuver against breast carcinoma have not yet brought about much improvement in curability. This discrepancy is based in part on the frequent development of blood-born metastases following resections of lesions which were considered as curable from the pathological standpoint. Applying new staining method of elastic fiber, contributed by Yokogawa and Kato of Cancer Institute, to 137 cases of breast carcinoma, resected on at Yokohama Minami Kyosai Hospital in the past decade, we investigated the significance of blood vessel invasion in the tumor itself. Victoria blue plus H-E staining was superior in that it did not disturb the coloring of H-E itself and that its staining of elastic fiber was so vivid as Elastica Goldner's method. The incidence of blood vessel invasion was 45% overall and was so high as 70%, referring to those cases with recurrence. Histologically the incidence was higher in lobular and medullary carcinoma. The invasive mode, increment of elastic fiber or lymphocyte infiltration around vessel did not show any statistically significant correlation with early recurrence. The presence of blood vessel invasion, however, was highly associated with early recurrence in cases with n1β or more lymph node metastases.
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