Abstract
AbstractThe detection of exceptional Rh phenotypes (apparently (– –DE–)) among Venezuelan Yanomamo Indians initiated investigation of the reactions of anti‐C (rh′) sera with bloods of the Rz phenotypes (CCDEE, CcDEE and CCDEe). It was concluded that since anti‐C reagents may contain differing amounts of two antibodies, anti‐C (rh′) and anti‐Ce (rhi), the choice of reagent is critical for the detection of Rz bloods, such that with an anti‐C serum containing large amounts of anti‐Ce relative to anti‐C, RzR2 (CcDEE) will be mistyped as R2R2 (ccDEE) and Rzr (R1R2‐CcDEe) may be mistyped as R2r (ccDEe). The error will have its greatest relative effect in populations characterized by substantial Rz frequencies and the consequences of such an error (depressed Rz gene frequency and elevated R2 gene frequency) are therefore illustrated from published Indian studies.
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