Blood to Plasma Ratio, Short-Term Stability and Plasma Protein Binding of Casiopeína IIgly, a Copper (II) Based Compound with Antineoplastic Activity

Abstract

Casiopeína IIgly is a mixed chelate coordination compound with copper (II) core that has shown important antineoplastic activity, even in some resistant cellular lines to Cisplatin. In this work, preclinical studies as blood to plasma ratio, plasma protein binding, short-term stability in blood and pharmacokinetics of this coordination complex are reported. The results indicate that Casiopeína IIgly is stable in blood at least for 6 hours at 37 °C. Also, this compound exhibits an important accumulation in whole blood rather than plasma fluid, a high plasma protein binding (>90%) as well as short half-life (47 min).