Blood Sugar Curves in Normal and Diabetic Dogs After Intravenous Injection of Insulin.

Abstract

The following report deals with the blood sugar curve after the intravenous injection of insulin into normal and depancreatized dogs. The study includes over 50 observations upon normal and 350 observations upon diabetic animals.Experiments on blood sugar lowering were performed on male dogs weighing 12 to 18 kilos, 18 hours after the last (afternoon) feeding and routine insulin injection. Doses from .02 to 1.0 units of insulin (Lilly) per kilo given in a volume of 1 cc. were injected into the jugular vein. Glucose determinations on tungstic acid filtrates were made by the Shaffer-Hartman method. The time intervals shown in the chart were found to bring out most clearly the differences in the 2 types of curves.The chart gives typical examples of time curves after the injection of 0.1 unit of insulin per kilo intravenously before and after removal of the pancreas. The upper curves show the results expressed in mg. % of blood sugar. The striking change in amount of sugar transported from blood to tissues by...