Blood serum concentration of troponin in patients with COVID-19 of various severities

Abstract

BACKGROUND: The search for available predictors of hospital survival and mortality rates during the COVID-19 pandemic is an urgent problem.
 AIM: The study aimed to determine the role of troponin in the immediate prognosis of patients with COVID-19.
 MATERIALS AND METHODS: The study included 85 patients with a new coronavirus infection upon admission, who underwent a blood test for troponin. All patients underwent an echocardiographic study according to a standard protocol, and the effect of troponin levels on nosocomial survival and mortality rates, correlation of this indicator with the left ventricular ejection fraction, degree of pulmonary hypertension, laboratory parameters, and degree of respiratory failure determined by computed tomography of the lungs and oxygen saturation indicators were analyzed. Correlation analysis with autopsy parameters was performed.
 RESULTS: A high level of troponin indicated the worst prognosis of patients during hospitalization. The laboratory marker level correlated significantly with the parameters of the left ventricular ejection fraction. Its highest level was determined in patients with type 1 myocardial infarction. Troponin was not correlated with the degree of respiratory failure, as well as the state of the myocardium in the autopsy material.
 CONCLUSIONS: Determining the troponin levels as a routine laboratory marker can be recommended for stratifying the risk of myocardial damage in patients with COVID-19 during hospitalization.