Abstract
The concentrations of blood pyruvic and α-ketoglutaric acids were measured chromatographically in malnourished and chronic alcoholic subjects suspected of being deficient in thiamine. The mean fasting levels of both were elevated, but after a loading dose of glucose, only pyruvate showed any marked further increase; the levels of each returned to normal following treatment with thiamine. Alterations in the concentration of the 2 keto acids are discussed in relation to the function of thiamine as part of a coenzyme for the decarboxylation of both keto acids. The value of estimating the keto acids in the diagnosis of thiamine deficiency is discussed. The concentrations of blood pyruvic and α-ketoglutaric acids were measured chromatographically in malnourished and chronic alcoholic subjects suspected of being deficient in thiamine. The mean fasting levels of both were elevated, but after a loading dose of glucose, only pyruvate showed any marked further increase; the levels of each returned to normal following treatment with thiamine. Alterations in the concentration of the 2 keto acids are discussed in relation to the function of thiamine as part of a coenzyme for the decarboxylation of both keto acids. The value of estimating the keto acids in the diagnosis of thiamine deficiency is discussed.
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