Abstract
Reduced diphosphopyridine nucleotide (NADH) was oxidized at abnormally rapid rates when mixed with sera from febrile infected patients. The pyruvate in sera, acting as a substrate for NADH-dependent serum enzymes, was found to be a critical determinant for this reaction. These data, which suggested abnormal levels of pyruvate and lactate in blood during infection, were confirmed by the determination of pyruvate and lactate in whole venous blood. Abnormally elevated levels of pyruvate were frequently found in the blood of infected patients, and the levels of pyruvate and lactate were significantly higher in the acute phase blood than those from the convalescent period. These findings are discussed in relation to the host's reaction to infection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
