Blood pulmonary tuberculosis biomarkers on diabetic individuals

Abstract

Event Abstract Back to Event Blood pulmonary tuberculosis biomarkers on diabetic individuals Carmen J. Serrano-Escobedo1, Rosa A. Gonzalez-Curiel1, Leonor Enciso-Moreno1, Noe Macias-Segura1 and Jose A. Enciso-Moreno1* 1 INSTITUTO MEXICANO DEL SEGURO SOCIAL, UNIDAD DE INVESTIGACION MEDICA ZACATECAS, Mexico SETTING. Tuberculosis (TB) associated to chronic health conditions such as non-insulin-dependent diabetes mellitus (NIDDM) could represent nowadays a worldwide Public Health threat. The relative odds of developing tuberculosis in diabetic patients ranges from 3 to 8 compared with non-diabetic patients. No molecular diagnostic or prognostic test to distinguish latent (LTB) from active TB (ATB) exists, neither biomarkers to follow TB pharmacology interventions. Given exacerbated inflammation by TB leads to pulmonary damage; key molecules on the inflammation process could be useful as diagnosis biomarkers for TB states, even in individuals with NIDDM. METHODS. Previous microarrays analysis at our laboratory identified a group of overexpressed genes on mice lungs infected with a Mycobacterium tuberculosis virulent strain that were not induced by a persistent strain that induces no inflammation. Based on the hypothesis that PBMCs from individuals with different TB infectious status could exhibit distinct transcription profiles, the present study evaluated the gene expression capability of 7 mice overexpressed genes on human whole blood, to discriminate subjects with pulmonary TB (PTB) (with or without NIDDM) from non infected or LTB subjects. RESULTS. In the no NIDDM group, CXCR5 presented lower expression on PTB compared to LTB, while PSTP1 expression was higher. On the other hand, NIDDM-PTB individuals showed higher expression for GBP2, ARHGAP30, NCF1, and FPR2 compared to the LTB individuals, while CXCR5 expression was lower. CONCLUSIONS. Gene expression profile of four overexpressed genes on TBA were found with potential utility to discriminate on NIDDM, LTB persons from those with activated pulmonary TB. Acknowledgements This study was supported by the Mexican Council for Science and Technology (grant CONACYT-SALUD-2011-1-161677) Keywords: Tuberculosis, diabetes, biomarkers, Inflammation, Blood Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Host-pathogen interactions Citation: Serrano-Escobedo CJ, Gonzalez-Curiel RA, Enciso-Moreno L, Macias-Segura N and Enciso-Moreno JA (2013). Blood pulmonary tuberculosis biomarkers on diabetic individuals. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00056 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Jose A Enciso-Moreno, INSTITUTO MEXICANO DEL SEGURO SOCIAL, UNIDAD DE INVESTIGACION MEDICA ZACATECAS, ZACATECAS, ZACATECAS, 98000, Mexico, enciso_2000@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Carmen J Serrano-Escobedo Rosa A Gonzalez-Curiel Leonor Enciso-Moreno Noe Macias-Segura Jose A Enciso-Moreno Google Carmen J Serrano-Escobedo Rosa A Gonzalez-Curiel Leonor Enciso-Moreno Noe Macias-Segura Jose A Enciso-Moreno Google Scholar Carmen J Serrano-Escobedo Rosa A Gonzalez-Curiel Leonor Enciso-Moreno Noe Macias-Segura Jose A Enciso-Moreno PubMed Carmen J Serrano-Escobedo Rosa A Gonzalez-Curiel Leonor Enciso-Moreno Noe Macias-Segura Jose A Enciso-Moreno Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.