Abstract
Type 2 diabetes in children is a recent phenomenon, and current evidence about diabetes and hypertension is based on adult studies. Adults with diabetes have changes in 24-h ambulatory blood pressure (BP) profiles, including a decrease in sleep dip (the decline in BP that normally occurs during sleep) and increased systolic blood pressure (SBP), that are associated with early cardiovascular disease (1). This cross-sectional study compared 24-h BP and heart rate (HR) profiles of Hispanic and African-American adolescents recently diagnosed with type 2 diabetes with the profiles of two groups of 10 healthy control subjects matched for age, sex, height, and …
Highlights
We assayed Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) levels in vitreous samples from 50 consecutive patients with proliferative diabetic retinopathy (PDR) (31 patients) and macular hole who underwent pars plana vitrectomy
PlGF is detected in the fibrovascular membranes of PDR [2], and PlGF mRNA expression significantly increases in retina during diabetic retinopathy [6]
Adults with diabetes have changes in 24-h ambulatory blood pressure (BP) profiles, including a decrease in sleep dip and increased systolic blood pressure (SBP), that are associated with early cardiovascular disease [1]
Summary
Pancreas transplantation for patients with type 1 diabetes (Position Statement). Diabetes Care 25 (Suppl. 1):S111, 2002 2. Glimepiride is a sulfonylurea that lowers blood glucose levels by stimulating insulin secretion from pancreatic -cells and secondarily by increasing glucose uptake in peripheral tissues [3] Such action mechanisms might be suitable for the treatment of glucocorticoid-induced diabetes. At 1–2 years after starting the glucocorticoid therapy, they showed overt diabetes, with mean fasting blood glucose 12.6 Ϯ 0.7 mmol/l and HbA1c 9.5 Ϯ 1.5% (means Ϯ SE) Their index for pancreatic -cell function (HOMA-%), as determined by the correct homeostasis model assessment evaluation [4], was 27 Ϯ 8%, significantly (P Ͻ 0.001) lower than that (72 Ϯ 4% [range 44 –111%]) in 24 healthy Japanese control subjects (mean age 47 Ϯ 2 years) who had normal glucose tolerance by 75-g oral glucose tolerance test. From the 1Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; and the 2Department of Internal Medicine, Kinki Central Hospital, Itami, Japan
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