Abstract
Purpose: The aqueous extract of Euphorbia hirta (E. hirta) was evaluated for hypotensive effect in normotensive Wistar rats at the dose of 0.625-40 mg/kg. Methods: The aqueous extract of the aerial parts of E. hirta was evaluated for hypotensive effects in thiopentone/urethane (20/1250 mg/kg) anaesthetized normotensive Wistar rats in the presence and absence of atropine (1.0 mg/kg), at the graded doses of 2.5-40 mg/kg. Results: The aqueous extract of E. hirta caused a dose-dependent decrease in the systolic, diastolic, and mean arterial pressure in normotensive Wistar rats. The extract significantly reduced the systolic blood pressure from resting blood pressure levels of 125.63 ± 4.27 to 1363.6 ± 2.92 (p < 0.01), 107.41 ± 5.45 (p < 0.05), 102.03 ± 4.61 (p < 0.01), 98.93 ± 4.57 (p < 0.01) at the doses of 0.625, 5.0, 10.0, 20.0 and 40.0 mg/kg respectively, while the effect of the extract at the doses of 1.25 and 2.5 mg/kg respectively of 114.43 ± 6.36 and 113.8 ± 5.76 mmHg were not significant (p > 0.05). Atropine (1 mg/kg) abolished the dose-dependent hypotensive effect of the extract. Conclusion: We conclude that the aqueous extract of E. hirta has hypotensive effect in normotensive Wistar rats. Keywords: Blood pressure, normotensive, Euphorbia hirta, mean arterial pressure, thoracic aorta
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
