Abstract
The influence of serum from patients with essential hypertension on the sodium efflux rate constants of human lymphocytes and on the activity of isolated (Na+ + K+)-ATPase was investigated. The ouabain-sensitive sodium efflux rate constant was significantly decreased (p less than 0.001) in the sera of 19 hypertensives (1.92 +/- 0.11 h-1) compared with the sera of 30 normotensives (2.44 +/- 0.07 h-1). The ouabain-insensitive sodium efflux was unaffected. These results corresponded with a significant difference (p less than 0.005) of (Na+ + K+)-ATPase activity (1.03 +/- 0.04 mU/ml and 0.079 +/- 0.06 mU/ml), when an isolated (Na+ + K+)-ATPase was incubated with the sera of 22 normotensives or 18 hypertensives. Both the rate constant of ouabain-sensitive sodium efflux and the (Na+ + K+)-ATPase activity correlated significantly with the diastolic and systolic blood pressure (p less than 0.001). These data, therefore, demonstrated the close relationship between essential hypertension and the concentration of a circulating inhibitor of the sodium pump.
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