Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

Abstract

To the Editor: In the Halt Progression of Polycystic Kidney Disease (HALT-PKD) study, Schrier et al. (Dec. 11 issue)1 randomly assigned patients with early-stage autosomal dominant polycystic kidney disease (ADPKD) to either a standard blood-pressure target or a low blood-pressure target. The low blood-pressure target was associated with a slower increase in total kidney volume, but not with an overall change in the estimated glomerular filtration rate (GFR). The latter finding might be viewed as being disappointing. However, we would caution that the institution of strict blood-pressure control will result in an acute, hemodynamic, but reversible decrease in the estimated . . .