Abstract
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features. We propose an extensive review of mechanisms of passive self-separation technologies and enumerate some experimental details and devices to exploit these effects. The performances, limitations and challenges of these technologies and devices are also compared and discussed.
Highlights
Published: 3 July 2021Many recent advancements are developed in the Lab-on-a-chip field
This review has primarily focused on the passive blood-plasma self-separation techniques, emphasized the basic mechanisms of passive separation methods without microfiltration and introduced novel applications based on these theories
The passive bloodplasma self-separation technique is a possible candidate for LOC applications and overcomes many blood plasma separation challenges
Summary
Many recent advancements are developed in the Lab-on-a-chip field. the promotion of point-of-care (POC) technology is still an issue. The viscosity of the blood antigens arethe usually suspended in the plasma and are used as biomarkers ovarian cancer sample affects design of the microfluidic devices. With this small-scale blood sample, microchannel size is limited Due to this limitation, many hydrodynamic methods cannot have full effects on the plasma separation, such as the. Will the conclude and driven flow in the microchannels, surface treatments are needed we when channel provide possible future directions for passive blood plasma self-separation in microfluidic materials are naturally hydrophobic. For comparison analysis is made to provide a better view of recent advances in the passiv blood plasma self-separation technology in the LOC field. We will conclud and provide possible future directions for passive blood plasma self-separation i microfluidic applications
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