Blood oxylipin profiles as a marker of the pathogenesis of oncological diseases

Abstract

Oxylipins are signal lipids derived from polyunsaturated fatty acids (PUFAs), which are formed by polyenzymatic multi-acid pathways of danger (cyclooxygenase, lipoxygenase, epoxygenase, anandamide), as well as non-enzymatically. These PUFA transformation pathways are activated in parallel, forming a mixture of active inclusions. Although the combination of oxylipins with tumor secretions was performed a long time ago, the methods of instrumental analysis have only recently been improved, measurements of oxylipins of different classes (profiles) have been compared. The review considers approaches to obtaining the profile of oxylipins by HPLC-MS/MS. The profiles of oxylipins in samples of patients with oncological diseases (breast cancer, colorectal cancer, ovarian cancer, lung cancer, prostate cancer, liver cancer) were compared. The conclusion is made about the possible possibilities of using the profile of blood oxylipins as markers of oncological diseases. Understanding the high level of exceeding the level of PUFAs and the physiological activity of oxylipin mixtures will be accompanied by the perfection of early diagnosis and prediction of the course of tumor diseases.