Abstract
We propose and demonstrate a single-laser-based sensing method for measuring both blood oxygenation and microvascular blood flow. Based on the optimal wavelength range found from theoretical analysis on differential absorption based blood oxygenation measurement, we designed and fabricated a 720-nm-band wavelength tunable V-cavity laser. Without any grating or bandgap engineering, the laser has a wavelength tuning range of 14.1 nm. By using the laser emitting at 710.3 nm and 724.4 nm to measure the oxygenation and blood flow, we experimentally demonstrate the proposed method.
Highlights
The microcirculation plays an essential role in health care, and abnormalities in the microvascular function often occur at the preliminary stages of the microvascular diseases
Since the 720-nm-band widelytunable V-cavity laser has the features of compactness, fabrication simplicity and easy wavelength control, the technology has potential advantages of low cost, low power consumption, small size and easy control, which is suitable for wearable health monitoring devices
The wavelength band around 720nm is shown to have the highest sensitivity for a given tuning range for blood oxygen saturation measurement
Summary
The microcirculation plays an essential role in health care, and abnormalities in the microvascular function often occur at the preliminary stages of the microvascular diseases. Microvascular blood flow and tissue oxygenation are two critical parameters to assess the microvascular function and its abnormal changes. Their detection and monitoring can provide early disease diagnosis and prevention, such as hypertension, edema and hypoxemia [1,2,3]. Microvascular blood flow can be directly accessed using a laser Doppler flowmeter (LDF) [4, 5] and tissue oxygenation can be obtained using transmissive or reflective pulse oximeter [1,2,3, 6, 7]. We propose and investigate a single-laser-based sensing method for both blood oxygenation and microvascular blood flow measurements. Since the 720-nm-band widelytunable V-cavity laser has the features of compactness, fabrication simplicity and easy wavelength control, the technology has potential advantages of low cost, low power consumption, small size and easy control, which is suitable for wearable health monitoring devices
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