Abstract
Objective: to study the effect of reproductive hormones on the blood lipoprotein spectrum in the postresuscitation period after cardiac arrest. Materials and methods. Experiments were carried out on 66 mature albino rats of either sex weighing 200—250 g. Ten-minute cardiac arrest was induced by intrathoracic ligation of the vascular bundle. At 30 min after resuscitation, 49 animals were intramuscularly injected placebo and 17 animals were administered gyn-odian depot (Schering, Germany). The investigators measured the plasma concentrations of progesterone, 17-OH progesterone, androstenedione, dehydroepiandrosterone sulfate, testosterone, estradiol, and estriol, as well as the levels of triglycerides, total, and high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) cholesterols. Blood was sampled on days 2 and 16 in the absence of therapy and on day 16 of sex steroid therapy. Results. By day 2 postresuscitation, the progesterone/estradiol ratio increased by approximately 1.8 times in males and females. Despite the fact that there were no changes in the concentrations of triglycerides, VLDL and HDL cholesterols in both males and females at that time, but the level of LDL cholesterol increased. Gender-related differences in the LDL spectrum by day 2 postresuscitation remained only in the levels of LDL cholesterol. Despite the normalization of progesterone levels, the concentrations of triglycerides and VLDL cholesterol decreased by day 16 of the postresuscitative period in the absence of therapy. There were no gender-related differences in the lipoprotein spectrum at this stage. The exogenous estradiol in combination with dehydroepiandrosterone caused a significant increase in the concentration of HLD cholesterol and a reduction in that of VLDL cholesterol in males and females both. Conclusion. Under gynodian action, the lipid spectrum was indicative of the exogenous estra-diol and dehydroepiandrosterone sulfate activation of the receptor transport of polyunsaturated fatty acids to the cells and that of reverse cholesterol outflow from the cell membranes in the resuscitated animals. Key words: cardiac arrest, reproductive steroids, blood lipoproteins, gynodian, postresuscitation period.
Highlights
Цель исследования — изучение влияния репродуктивных гормонов на состояние спектра липопротеинов крови в постреанимационном периоде после остановки сердца
Despite the fact that there were no changes in the concentrations of triglycerides, very low den sity lipoprotein (VLDL) and high density lipoprotein (HDL) cholesterols in both males and females at that time, but the level of low density lipoprotein (LDL) cholesterol increased
Despite the normalization of progesterone levels, the concentrations of triglycerides and VLDL cholesterol decreased by day 16 of the postresuscitative period in the absence of therapy
Summary
Работами нашего института показано ускорение постреанимационного восстановления под действием экзогенных репродуктивных гормонов, а также разли чия изменений головного мозга и сроков восстановле ния неврологических нарушений после перенесенной остановки сердца в зависимости от пола [1, 2]. Эст рогены повышают концентрацию липопротеинов высо кой плотности (ЛПВП) в результате стимулирования синтеза белка апо А 1 в печени и индуцируют экспрес сию синтеза SR B1 рецепторов, обеспечивающих выход ХС из ЛПВП в печень и в клетки, синтезирующие сте роиды. Обеспечивающих активный транспорт полиненасыщен ных жирных кислот в клетки в составе липопротеинов низкой плотности (ЛПНП), снижая тем самым концен трацию ЛПНП в крови. В результате ингибирования активности липопротеидлипазы, катализирующей де градацию липопротеинов очень низкой плотности (ЛПОНП), эстрогены повышают концентрацию их в крови [10,11,12]. Прогестерон и андрогены, в основном ингибируя антиатерогенный эффект эстрогенов, подав ляют синтез ТГ в гепатоцитах и клетках тонкого кишеч ника и снижают концентрацию ЛПОНП в крови в ре зультате повышения активности липопротеидлипазы [10]. Цель исследования — изучение влияния репро дуктивных гормонов на динамику спектра липопротеи нов крови в постреанимационном периоде после оста новки сердца
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