Abstract
Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis. Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle-Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. ReVman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference (MD) and 95% confidence interval (95% CI). The heterogeneity test was conducted according to I2 and Q tests. Egger's test was used to quantitatively evaluate publication bias. This analysis involved 12 studies (12,395 subjects). The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC) (MD = 0.11mmol/L, 95%CI: - 0.03, 0.25; I2 = 21%; P = 0.36), triglycerides (TG) (MD = - 0.01mmol/L, 95%CI: - 0.09, 0.07; I2 = 6%; P = 0.34), and low-density lipoprotein cholesterol (LDL-C) (MD = 0.10mmol/L, 95%CI: 0.00, 0.19; I2 = 0%; P = 0.74) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C (MD = 0.02mmol/L, 95%CI: - 0.09, 0.13; I2 = 0%; P = 0.74) in postmenopausal women in osteopenia. TG (MD = - 0.04mmol/L, 95%CI: - 0.14,0.07; I2 = 49%; P = 0.07) was unchanged in the osteoporosis (OP) group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group (MD = 0.05mmol/L, 95%CI: 0.03, 0.07; I2 = 31%; P = 0.15) but not in osteopenia group (MD = 0.01mmol/L, 95%CI: - 0.01, 0.02; I2 = 38%; P = 0.14) in all subjects. HDL-C was elevated in patients with OP.
Highlights
Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis
There were no significant differences in low-density lipoprotein cholesterol (LDL-C) in postmenopausal women in osteopenia
high-density lipoprotein cholesterol (HDL-C) was elevated in OP group but not in osteopenia group in all subjects
Summary
Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis. Osteoporosis (OP) is a disease characterized by reduced bone mineral density (BMD) and an increased risk of osteoporotic fractures. It is one of the most common metabolic diseases in the elderly population. This poses a serious health concern worldwide[1] because osteoporotic fractures are the leading cause of disability and death in elderly patients[2] The onset of this disease is associated with various factors, including aging, gender, insufficient calcium intake, vitamin D deficiency, low body mass index (BMI), decreased physical activity[3], and hyperthyroidism[4]. Whether an increase in blood lipid levels can protect patients from the development of OP is not well understood The aim of this meta-analysis was to extract blood lipid indicators in patients with osteopenia, or OP from case-control studies and to determine their levels
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