Abstract
Objective: to study the blood levels of free fatty acids (FFA) and adenyl nucleotides in patients with acute acetic acid poisoning (AAAP) complicated with exotoxic shock (ES). Subjects and methods. The study enrolled 33 patients with severe AAAP (with (n=10) and without (n=23) ES), of them there were 5 deaths. The patients’ age was 31.6±11.6 years. A control group comprised 16 healthy individuals. The total level of FFA and the concentration of glycerol were measured in the plasma. Red blood cells were as an object for investigation of ATP, ADP, and AMP. Hearts were morphologically studied in 5 patients died from shock. The data were statistically processed using the Mann-Whitney rank nonparametric tests. The differences were regarded as statistically significant at the achieved significance level of pConclusion. Microscopic studies of the hearts from the deceased patients revealed multiple cardiomyocyte necroses. All the patients with severe AAAP showed a considerably elevated blood level of FFAs with their impaired myocardial utilization and decreased red blood cell ATP and ADP concentrations. The most pronounced changes were found in a group of patients with AAAP and ES. Key words: acetic acid poisoning, exotoxic shock, free fatty acids, energy-rich phosphates.
Highlights
Цель исследования — изучить содержание свободных жирных кислот (СЖК) и адениловых нуклеотидов крови боль ных с острым отравлением уксусной кислотой (ООУК), осложненным экзотоксическим шоком (ЭШ)
The total level of free fatty acids (FFA) and the concentration of glycerol were measured in the plasma
Red blood cells were as an object for investigation of ATP, ADP, and AMP
Summary
Цель исследования — изучить содержание свободных жирных кислот (СЖК) и адениловых нуклеотидов крови боль ных с острым отравлением уксусной кислотой (ООУК), осложненным экзотоксическим шоком (ЭШ). У всех пациентов с ООУК тяжелой степени отмечено существенное повышение в крови уровня СЖК с нару шением их утилизации миокардом и снижение содержания в эритроцитах АТФ и АДФ. Objective: to study the blood levels of free fatty acids (FFA) and adenyl nucleotides in patients with acute acetic acid poi soning (AAAP) complicated with exotoxic shock (ES). All the patients with severe AAAP showed a considerably elevated blood level of FFAs with their impaired myocardial utilization and decreased red blood cell ATP and ADP concentrations. Работ по изучению уровня СЖК и макроэргичес ких фосфатов в крови больных с острым отравлением уксусной кислотой нет. Цель исследования — изучить содержание уров ня СЖК и адениловых нуклеотидов крови больных с ООУК, осложненным ЭШ
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
