Abstract

Abstract. Arterial blood lactate, pyruvate, plasma β‐hydroxybutyrate and acetone have been followed in 12 patients with diabetic ketoacidosis during the initial 24‐hour treatment period. In all cases the acidosis was fully explained by the accumulation of ketone bodies, and blood lactate and pyruvate never exceeded normal values. A slight rise was, however, observed in blood lactate in some patients during the treatment. Some possible explanations of this phenomenon are discussed. β‐hydroxybutyrate was cleared from the plasma much faster than acetone, and the ratio between the ketone bodies was constantly changing during treatment of the acidosis.

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