Abstract
In the preceding chapter, different physiological, chemical, and bio-chemical barriers in systemic drug delivery have been introduced. In this chapter, we will talk about the interactions between nanoparticles and blood components, and will delineate strategies to enhance the compatibility of the nanoparticles in blood. In fact, in order to achieve systemic delivery, blood circulation plays an important role because it is the blood that helps deliver the therapeutics to tissues bodywide. A good understanding of the interactions between nanoparticles and various components in blood is, therefore, pivotal to proper design of nanoparticulate systems as effective systemic carriers. The objective of this chapter is to introduce the methods of manipulating the pharmacokinetics and biodistribution of nanoparticulate systems by manipulating the interactions between nanoparticles and blood components during systemic delivery. Strategies to improve the hematocompatibility of the nanoparticulate systems will also be discussed for enhancing the use of the carriers in practical interventions at the preclinical and clinical levels.
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