Abstract
Background: We conducted an analysis to check whether the ABO blood group impacts the susceptibility or protection against different types of head and neck cancers. Method: We analyzed the medical records of 61,899 cancer patients from “Prof. Dr. Alexandru Trestioreanu” Institute of Oncology from Bucharest, along with the corresponding blood group type. Data were scraped using Python. For analysis, we used Chi-square test. Results: The blood group count was A (245, 45.12%) followed by 0 (160, 24.66%), B (110, 20.26%), and AB (28, 5.16%). Hypopharyngeal cancer was associated with B group, oral cavity cancer was associated with a lower risk in patients with B group while AB patients had a higher risk for oral cavity cancer (χ2 = 36.136, df = 18, p = 0.007). Conclusion: Blood group B is associated with an increased incidence for hypopharyngeal cancer, whereas, for the oral cavity, was associated lower incidence. Blood antigen A is associated with a higher risk of oral cavity cancer development, independent of B blood antigen.
Highlights
The ABO blood group systems antigens were discovered in late 1900 and are considered by many the first human genetic markers. [1] Over the last five decades, studies focusing on ABO antigens found that those are expressed on the surface of many other cells than red blood cells, including epithelial and endothelial cells [2]
Hypopharyngeal cancer was associated with B group, oral cavity cancer was associated with a lower risk in patients with B group while AB patients had a higher risk for oral cavity cancer (χ2 = 36.136, df = 18, p = 0.007)
We had an initial enrollment of 61,899 patients, and after excluding the patients for which the blood group was missing from their medical charts, 19,626 patients remained
Summary
The ABO blood group systems antigens were discovered in late 1900 and are considered by many the first human genetic markers. [1] Over the last five decades, studies focusing on ABO antigens found that those are expressed on the surface of many other cells than red blood cells, including epithelial and endothelial cells [2]. [1] Over the last five decades, studies focusing on ABO antigens found that those are expressed on the surface of many other cells than red blood cells, including epithelial and endothelial cells [2] This further led to research regarding an existing link between ABO antigens and chronic diseases, including malignancies [3–5]. Recent research in medical oncology focused on different types of cancer, depending on their frequency, identifying a series of diverse factors [7] which influenced the evolution of the disease as well as the treatment outcome. While these results led to new therapeutic approaches [8] which generated better treatment outcomes even in metastatic stages [9,10], cancer is still one of the leading causes of death in the EU and USA [11,12]. Blood antigen A is associated with a higher risk of oral cavity cancer development, independent of B blood antigen
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