Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease.

Zixiang Ye,Jingyi Ren,Wenquan Niu,Xiaozhai Yu,Ziyu Guo,Yike Li,Linying Shi,Yanxiang Gao,Jingang Zheng,Yimin Tu,Peizhao Li,Mulei Chen,Qing Li,Enmin Xie,Yaxin Wu

doi:10.3389/fcvm.2021.821540

Abstract

ObjectiveOur study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis.MethodsA total of 408 ESRD patients with dialysis between January 2010 and December 2020 were enrolled including 204 patients diagnosed with CAD undergoing coronary angiography for the first time, and baseline characteristics as well as Gensini score (GS) were collected. Logistic regression analysis and linear regression analysis were performed to evaluate the relation of ABO blood types to the risk and severity of CAD, respectively.ResultsBlood group O frequency was significantly low in dialysis ESRD patients with CAD (25 vs. 38.24%) compared with the non-CAD patients and multivariable logistic regression showed blood group O was negatively associated with the risk of CAD [adjusted odds ratio (OR) = 0.33, 95% CI = 0.19–0.60, p < 0.001] as well as the GS tertiles (adjusted OR = 0.23, 95% CI = 0.11–0.49, p < 0.001) compared with A blood group. Blood group A, B, and AB were positively associated with the high Gensini tertile compared with O blood group (adjusted OR = 4.26, 95% CI = 2.03–8.93, p < 0.001; adjusted OR = 2.39, 95% CI = 1.11–5.13, p < 0.05; adjusted OR = 4.33, 95% CI = 1.40–13.35, P < 0.05). Similarly, multivariable linear regression results revealed O blood type was negatively associated with the GS (β = −26.129, 95% CI = −40.094 to −12.164, p < 0.001).ConclusionThis case-control study demonstrated that blood group O was a potential independent protective factor for the risk and severity of CAD in ESRD patients with dialysis.

Highlights

Cardiovascular disease is a kind of serious and common disease with high morbidity and mortality [1]
Our study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis
Blood group O frequency was significantly low in dialysis End-stage renal disease (ESRD) patients with CAD (25 vs. 38.24%) compared with the non-CAD patients and multivariable logistic regression showed blood group O was negatively associated with the risk of CAD [adjusted odds ratio (OR) = 0.33, 95% CI = 0.19–0.60, p < 0.001] as well as the Gensini score (GS) tertiles compared with A blood group

Summary

Introduction

Cardiovascular disease is a kind of serious and common disease with high morbidity and mortality [1]. Chronic kidney disease (CKD) is a high-incidence disease, and more than 14% of people suffered from CKD in the United States [3]. Cardiovascular disease serves as the major cause of death in patients with CKD worldwide [4], because these patients are exposed to many cardiovascular disease risk factors, such as diabetes, inflammation, and oxidative stress [5]. End-stage renal disease (ESRD) is the final stage of CKD with irreversible kidney function dysfunctions. It is reported that cardiovascular disease was responsible for more than half of all deaths among the patients with ESRD [6]. There are many potential factors leading to cardiovascular disease in patients with ESRD, it has not been studied whether ABO blood groups served as an independent predictor for cardiovascular disease in ESRD groups with dialysis

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Conclusion