Blood group A2B with anti-A1 antibody reacting at 37 °C – A case report

Abstract

Blood group A2 and A2B are extremely rare blood groups. 22–26% of A2B individuals can have anti-A1 antibody which reacts at a temperature below 25°C and do not pose problem in transfusion. Reactivity of anti-A1 at 37°C can leads to haemolytic transfusion reaction if a compatible unit is not found and a least incompatible unit is transfused therefore an anti-A1 antibody having a thermal range up to 37°C is called as clinically significant. We report a case of A2B with anti-A1 antibody reacting at 37°C.