Abstract
IntroductionStudies have been performed to identify the association between ABO blood groups and coronary artery disease. However, data is scarce about the impact of ABO blood groups on heart rupture (HR) after acute myocardial infarction (AMI).MethodsWe conducted a retrospective case–control study that included 61 consecutive patients with HR after AMI during a period from 1 January 2012 to 1 December 2019. The controls included 600 patients who were selected randomly from 8143 AMI patients without HR in a ratio of 1:10. Univariate and multivariate logistic regression analysis were used to identify the association between ABO blood groups and HR.ResultsPatients with blood group A had a greater risk of HR after AMI than those with non-A blood groups (12.35% vs 7.42%, P < 0.001). After adjusting for age, gender, heart rate at admission, body mass index (BMI), and systolic blood pressure (SBP), blood group A was independently related to the increased risk of HR after AMI (OR = 2.781, 95% CI 1.174–7.198, P = 0.035), and remained as an independent risk factor of HR after AMI in different multivariate regression models.ConclusionBlood group A is significantly associated with increased HR risk after AMI.
Highlights
Studies have been performed to identify the association between ABO blood groups and coronary artery disease
heart rupture (HR) was specified as free wall rupture (FWR), ventricular septal rupture (VSR) and papillary muscle rupture (PMR)
acute myocardial infarction (AMI) was classified as ST-segment elevation myocardial infarction (STEMI) and non- ST-segment elevation myocardial infarction (NSTEMI), the diagnostic criteria refer to our previous study [19]
Summary
Studies have been performed to identify the association between ABO blood groups and coronary artery disease. Data is scarce about the impact of ABO blood groups on heart rupture (HR) after acute myocardial infarction (AMI). Heart rupture (HR) was one of the fatal complications after acute myocardial infarction (AMI) though its incidence decreased dramatically in reperfusion era nowadays [1,2,3]. HR was specified as free wall rupture (FWR), ventricular septal rupture (VSR) and papillary muscle rupture (PMR). In the pre-perfusion time, the incidence of FWR was about 2–6%, accounting for up to 30% of the in-hospital death after AMI [3,4,5]. VSR happened in approximately 1–3% AMI population before the. Fu et al BMC Cardiovasc Disord (2020) 20:471
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