Abstract
Objective: To evaluate the hypoglycemic effect of Avartaki Churna (Cassia auriculata Linn.) in experimental animals. Materials and Methods: Avartaki Churna was prepared by the standard procedure of Churna Kalpana. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intra-peritoneal [i.p.]) 35 mg/kg. After assessment of hyperglycemia as an approximate induction of diabetes, Group IV animals were treated with 300 mg/kg of Avartaki Churna. For treatment comparison, Group III animals were treated with a standard hypoglycemic drug, glibenclamide 1 mg/kg. Blood sugar level was assessed by glucometer on the 7th, 14th, 21st and 28th  day. Results: Avartaki Churna produced a significantly reduction of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, Avartaki Churna produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: Avartaki Churna and glibenclamide significantly reduced blood sugar level. The results were more significant with successive days in this in vivo comparative study.Â
Highlights
In A yurveda Prameha/Madhumeha can be considered as Diabetes Mellitus by different perspectives based on clinical symptoms and attempts have been made by A yurvedic physicians and researchers to treat these two entities by using classical formulations mentioned in Prameha Chikitsa.(1) The first and most elaborated description of A vartaki in a classical text is available in Kaiyadeva Nighantu, where it’s Pramehaghna/ Madhumehaghna action through different botanical parts of plant has been mentioned
The base line value in all four groups of albino rats showed that the fasting blood glucose (FBG) levels were within normal limits
The results indicate a prolonged action in a reduction in blood glucose by A vartaki Churna and are probably mediated through enhanced secretion of insulin from β-cells of Langerhans or through an extrapancreatic mechanism
Summary
In A yurveda Prameha/Madhumeha can be considered as Diabetes Mellitus by different perspectives based on clinical symptoms and attempts have been made by A yurvedic physicians and researchers to treat these two entities by using classical formulations mentioned in Prameha Chikitsa.(1) The first and most elaborated description of A vartaki in a classical text is available in Kaiyadeva Nighantu, where it’s Pramehaghna/ Madhumehaghna action through different botanical parts of plant has been mentioned. Kaiyadeva Nighantu is written by Kaiyadeva in 15th century. According to Kaiyadeva Nighantu, the flower has Pramehashamana property. The seeds are said to be Madhumehaghna, and the root is used as Pramehaghna.(2). A major lifestyle disease is undoubtedly the most challenging public health problem of 21st century with a worldwide prevalence of 387 million (8.3%) and predicted to be 592 million by 2035. Once known as the ‘diabetes capital of the world’ was home to 61.3 million patients with T2DM in 2011 with predictions of 101.2
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