Abstract
Azadirachta indica A. Juss (Neem) is a medicinal plant that contains antioxidants, antihyperlipidemia, and has antidiabetic activity. This research aimed to examine the effect of neem leaf ethanolic extract on blood glucose levels of white rats given high-fat rations. The male white rats (Rattus norvegicus L.) with two months of age were used. The treatment of test animals consisted of six treatment groups and four replications, namely: the control group (P0); given high fat rations + duck egg yolk 2.5 ml/200gBW (P1); given high-fat rations + 8 mg/200gBW simvastatin (P2); and P1+ the dose of neem leaf ethanolic extract of 75; 100; and 125 mg/200gBW (P3; P4; and P5). Blood-glucose levels were analyzed by colorimetric enzymatic method using Roche Diagnostics Cobas C reagents kits. Blood-glucose level was determined using Roche / Hitachi cobas c systems automatically. Homogeneous and normally distributed data of blood-glucose levels, body weight and feed consumption were analyzed statistically using ANOVA followed by Duncan's test with a significance level of 5% using SPSS 16.0 software. The results indicated that giving the neem leaf ethanolic extract of could reduce the blood glucose levels. In this study, it was concluded that the neem leaf ethanolic extract of could potentially be used as an alternative to cure diabetes mellitus.
Highlights
The times have gradually influenced people's lifestyle and diet
Hyperlipidemia is identified by an increase in total cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), and reduced levels of high density lipoprotein (HDL)
The results of this study indicated an increase in blood glucose levels after the oral administration of high fat ration with a high enough fat content (12.07% WB) and chlolesterol (0.74mg/g) compared to a commercial ration with 4.70% WB fat and 0.48 mg/g cholesterol content (Table 1 and 2)
Summary
The times have gradually influenced people's lifestyle and diet. People today tend to have a habit of consuming high-fat foods which can lead to an increase in the prevalence of degenerative diseases, one of which is diabetes mellitus (Foley et al, 2019). Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract. Isdadiyanto et al (2020) stated that white mice given high-fat rations and 44 days of exposure to neem leaf ethanolic extract showed an increase in HDL concentrations and a decrease in triglycerides and LDL concentrations.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biosaintifika: Journal of Biology & Biology Education
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
