Blood glucose level, lipid profile and histopathology of alloxan induced diabetic rats fed Sesamum indicum compounded diet

Abstract

The purpose of this study was to examine the blood glucose level, lipid profile, and histology of alloxan-induced diabetic rats fed compounded diet of Sesamum indicum. 36 male albino rats were divided into nine groups of four each for a period of 21 days: normal control, diabetic control, treated with the standard medication glibenclamide, diabetic rats fed with 15%, 30%, and 60% compounded diet, and normal rats fed with 15%, 30%, and 60% compounded diet and induced with diabetics after 14 days. single intraperitoneal injection of freshly produced alloxan (120 mg/kg b.wt.) was used to induce diabetes. Acu-check glucometer was used to measure the blood glucose level, and conventional spectrophotometric method was used to measure the lipid profile level. When compared to the diabetic control group, which had glucose level above 200, the groups fed the compounded diet had decreased level. Significant (p<0.05) reduction was observed for cholesterol, triglyceride, and low-density lipoprotein when compared with diabetic control while the compounded diets were able to increase HDL that was found to be low in diabetic control. When compared to the diabetic control group, which displayed a damaged pancreas, the results from the histopathology of the pancreas showed that the groups fed with the compounded diet had a repaired pancreas. According to the study's findings, Sesamum indicum has the ability to reduce excessive blood glucose and cholesterol levels as well as mend a diabetic rat's deformed pancreas.