Abstract
Aim. To study the effect of repeated stress on blood glucose level in rats with various behavioral characteristics and with different resistance to the development of adverse consequences of negative emotiogenic exposures.
 Materials and Methods. The animals were initially subjected to open field test to calculate the index of activity. Daily 4-h immobilization of rats in individual plastic cages for 8 days was used as a model of stress. Blood glucose concentration was measured with a glucometer (control measurement and on the 1st, 3rd and 8th days of repeated stress).
 Results. The basal level of glucose in behaviorally active (stress-resistant) rats was lower than in passive (stress-predisposed) specimens. Repeated exposure of rats to stress resulted in development of hyperglycemia. However, the dynamics of blood glucose concentration was different in specimens with different parameters of behavior. The increase in glucose concentration in active animals was most pronounced after a single exposure. By the 3rd and 8th days of stress exposures, glucose level in these rats progressively decreased (as compared to the 1st day), but remained above the basal level. Passive specimens were characterized by the increase in blood glucose concentration after a single and, particularly, after three-time restraint stress. Glucose content in these animals slightly decreased by the 8th day (as compared to the previous periods), but was above the basal level.
 Conclusion. The dynamics of abnormalities in carbohydrate metabolism (in particular, changes in blood glucose level) during chronic emotiogenic exposures differed in specimens with different resistance to stress factors. These data illustrate the importance of an indivi-dual approach to studying the pathophysiological mechanisms of progression and development of stress-induced disorders.
Highlights
By the 8th day of repeated stress loads the blood glucose level in these rats decreased as compared to the preceding periods, but remained above the basal level
The blood glucose level in these rats decreased by the 3rd and 8th day of repeated exposures to stress in comparison with the 1st day of the experiment, but remained above the basal level
The results of our experiments indicate that the dynamics of disorders of carbohydrate metabolism in repeated stress, in particular, the blood glucose level, is different in specimens with different parameters of behavior and with different sensitivity to negative emiotiogenic factors
Summary
Изучение характера влияния повторных стрессорных воздействий на содержание глюкозы в крови крыс с разными поведенческими характеристиками, имеющих различную чувствительность к развитию негативных последствий отрицательных эмоциогенных воздействий. В исходных условиях содержание глюкозы у поведенчески активных крыс, прогностически устойчивых к стрессорным нагрузкам, меньше, чем у предрасположенных к стрессу, пассивных особей. В этих условиях динамика концентрации глюкозы в крови была различной у особей с разными параметрами поведения. Стрессорных воздействий уровень глюкозы у этих крыс прогрессивно снижался по сравнению с 1-ми сут. Пассивные особи характеризовались увеличением содержания глюкозы в крови после однократного и особенно трехкратного иммобилизационного стресса. Наблюдений уровень глюкозы у этих животных несколько уменьшался по сравнению с таковым в предыдущие периоды, но превышал исходное значение. Ключевые слова: многократные стрессорные воздействия, динамика глюкозы в крови, поведенчески пассивные и активные крысы, индивидуальная устойчивость к стрессу. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia (2)
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