BLOOD GLOBULINS REDUCING THE ANTICOAGULANT ACTIVITY OF HEPARIN

Abstract

The effect of serum and plasma pseudoglobulins on the prolonged thrombin and prothrombin time of heparinized plasma was studied. It was found that pseudoglobulins are able to shorten thrombin time and to a lesser degree prothrombin time. Experiments suggest that the following mechanism is involved: Pseudoglobulins replace heparin cofactor from heparin – heparin cofactor complex and, because the new complex acts as a weak antithrombin, the pseudoglobulins seem to possess antiheparin activity. Since euglobulins too have a weak antiheparin effect, no specificity can be ascribed to this phenomenon. Serum pseudoglobulins shorten also the prolonged thrombin time of incubated plasma, but not the prolonged prothrombin time. Plasma pseudoglobulins, however, because of their content in labile factor shorten both thrombin and prothrombin time.